Wilfredo Chiesa was born in Old San Juan and studied at the School of Plastic Arts of Puerto Rico. He has held over 30 international solo exhibitions and has participated in numerous group shows, including the Sao Paulo Biennial, the Cuenca Biennial, and the Ljubljana Biennial. Chiesa is Professor of Art at University of Massachusetts Boston, where he has been teaching for over 25 years. He has also taught at Wellesley College and at Bennington College, and has been a visiting artist and juror at many other academic institutions.

Chiesa’s works have been shown in many solo and group exhibitions internationally and are included in such public collections as The Museum of Modern Art, São Paulo; The Museum of Modern Art, Bogotá; La Casa del Libro, San Juan; Museum of Fine Arts, Boston; Harvard University; The Library of Congress, Washington DC; Bibliotheque Nationale, Paris; The International Print Museum, Fredrickstad; and The Institute for Art and Culture, Catania. 

In addition to painting, the artist has produced limited-edition artist books and public site-specific installations in Venice and New York. He created a mural painting commissioned by the School of Law at the University of Puerto Rico, which is permanently installed in their library's main reading room. 

Over the years, Chiesa has worked in Paris, Berlin, Madrid, Barcelona, Ibiza, Sicily, San Juan and Los Angeles.